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Common GI Medication and Their Side Effects: What You Should Know

January 17, 2025

Woman reading a list of side effects for the medication she was prescribed for her GI issues.

Insights from Dr. Andy Tau, Board-Certified Gastroenterologist

Why Gut Health Matters

Your digestive tract does more than just process food. When it’s functioning properly, you’ll notice:

  • Regular bowel movements
  • Minimal bloating, gas, or pain
  • Effective digestion and nutrient absorption

A healthy gut supports your immune system, helps maintain energy levels, and even plays a role in mental health. Disruptions in digestion can throw off your entire system—which is why GI medications are so commonly used.


Common Digestive Disorders

The physicians at Austin Gastroenterology frequently treat a variety of digestive conditions, including:

Irritable Bowel Syndrome (IBS)

Abdominal pain and changes in bowel habits without a clear physical cause.

Gastroesophageal Reflux Disease (GERD)

Stomach acid backs up into the esophagus, causing heartburn and regurgitation.

Functional Dyspepsia

Persistent upper abdominal discomfort, often triggered by meals, with no visible structural issue.

Inflammatory Bowel Disease (IBD)

Serious conditions like Crohn’s disease and ulcerative colitis that cause diarrhea, bloody stools, and urgency.


GI Medications: Benefits vs. Side Effects

Digestive medications are helpful, but they’re not without risks—especially with long-term or improper use. Here’s what you should know:

🔹 Antacids

  • Use: Quick relief from heartburn by neutralizing acid.
  • Side Effects: Constipation or diarrhea depending on formulation (e.g., calcium vs. magnesium). Effects are short-lived.

🔹 Proton Pump Inhibitors (PPIs)

  • Use: Treat GERD and ulcers effectively.
  • Side Effects: Nutrient malabsorption, increased infection risk, and “rebound acid” if stopped abruptly. Should be tapered gradually.

🔹 Histamine Blockers (H2 Blockers)

  • Use: Reduce acid production; helpful for occasional reflux.
  • Side Effects: Less effective over time due to tolerance buildup.

🔹 Promotility Agents

  • Use: Improve intestinal motility for conditions like gastroparesis.
  • Side Effects: Diarrhea, and in rare cases (e.g., tegaserod), cardiovascular risks.

🔹 Laxatives

  • Use: Relieve constipation.
  • Side Effects: Electrolyte imbalance and dependency with long-term use—especially stimulant types like senna.

The Hidden Risks of Over-the-Counter GI Medications

OTC doesn’t mean risk-free. Dr. Tau highlights several concerns:

  • Magnesium supplements – Can trigger diarrhea.
  • Pepto Bismol – May turn stools black, mimicking signs of internal bleeding.
  • Probiotics & fiber supplements – May cause bloating or gas if introduced too quickly.
  • Overuse of laxatives – Can lead to dehydration and weakened bowel function.

Why Are GI Issues Increasing?

Several trends may explain the rise in digestive disorders and medication use:

  • Increased focus on gut health and the microbiome
  • Post-COVID anxiety and depression, which are closely linked to gut-brain disorders like IBS
  • Frequent antibiotic use, leading to microbiome imbalance (aka dysbiosis)


Gut Health: Best Practices from Dr. Tau

For lasting digestive wellness, consider these daily habits:

✅ Eat a high-fiber, balanced diet
✅ Exercise regularly
✅ Manage stress
✅ Drink plenty of water

Should You Take Supplements?

Probiotics and prebiotics can help—but they’re not one-size-fits-all. Their success depends on your individual gut microbiome, which is still an area of active research. Dr. Tau advises choosing clinically studied strains and consulting a professional before starting any new supplement.


Final Thoughts

GI medications are essential for many, but they should be used wisely. Knowing the side effects and proper usage can help you avoid new problems while treating existing ones. When in doubt, always check in with a healthcare provider—especially for long-term symptoms or frequent medication use.

Keep up with the latest Austin Gastroenterology news by following us on Facebook or Instagram. To request an appointment with one of our board-certified physicians, use our online appointment request form. 

Filed Under: Digestive Health Tagged With: Best GI Doctor in Austin TX, Common GI Disorders, Common GI Issues, GI Doctor in Austin TX, gi doctor near me, GI Medication Side Effects

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Austin Gastroenterology offers dedicated care for various gastrointestinal and liver conditions through a range of in-office procedures, diagnostic and screening procedures, advanced endoscopic procedures in hospital, and other specialized GI care services. We have 18 offices throughout the greater Austin area, including GI care clinics, endoscopy centers, and infusion centers.